Imaging Biomarkers in Autoimmune Encephalitis
Limbic Encephalitis (LE) is an autoimmune disease defined by subacute short-term memory loss, psychatric abnormalities and often involves temporal lobe epilepsy. A variety of autoantibodies has been identified and associated with different subtypes of LE. We hypothesize that LE patients show stage-specific, side-specific and sero-specific structural and functional imaging correlates.
Our aim is to use a variety of multimodal imaging techniques, volumetric and surface-based analyses as well as network model approaches to identify those correlates and and utilize them in predictive analyses applying state-of-the-art machine learning approaches. Our hope is not only to differentially describe different entities covered by the umbrella term “limbic encephalitis”, but also contribute to a deeper understanding of the underlying pathologies.
Volumetry of hippocampal subfields in early and late stage in patients with VGKC-associated LE shows and stage- and serotype-specific patterns.
Tracts with reduced fiber cross-section in voltage-gated potassium channel (VGKC) autoantibody associated LE (left and middle) and reduced fiber density and cross-section in glutamic acid decarboxylase (GAD) autoantibody associated LE revealed by fixel-based analysis