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Subcortical grey matter volume and asymmetry

in the long-term course of Rasmussen’s encephalitis (2023)


Tobias Bauer, Johannes T Reiter, Selma Enders, Vera C W Keil,

Alexander Radbruch, Christoph Helmstaedter, Rainer Surges, Theodor Rüber

Brain Commun 2023. doi: 10.1093/braincomms/fcad324

Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study (2023)


Rebecca Kerestes, Andrew Perry,  Lucy Vivash, J. O’Brien, [...],

Johannes Reiter,  Antonella Riva,  Theodor Rüber, [...],

Ian H. Harding, the ENIGMA-Epilepsy Working Group

bioRxiv 2023. doi: 10.1101/2023.10.21.562994

Globally altered microstructural properties and network topology in Rasmussen’s encephalitis (2023)


Nina R. Held, Tobias Bauer, Johannes Reiter, Christian Hoppe,

Vera C. W. Keil, Alexander Radbruch, Christoph Helmstaedter,

Rainer Surges, Theodor Rüber

Brain Commun 2023. doi.: 10.1093

Volumetric gray matter findings in autonomic network regions of people with focal epilepsy (2023)


Elisabeth Neuhaus, Felix BitzerNina R HeldTobias Bauer,

Jennifer Gaubatz, Randi von Wrede, Tobias Baumgartner , Atilla Rácz,

Vitali Becker, Rainer Surges, Theodor Rüber

J Neuroimaging 2023. doi: 10.1111/jon.13164

A novel geometry-based analysis of hippocampal morphometry in mesial temporal lobe epilepsy (2023)

Fundus autofluorescence imaging using red excitation light (2023)

Mesiotemporal Volumetry, Cortical Thickness, and Neuropsychological Deficits

in the Long-term Course of Limbic Encephalitis (2023)

Antonia Harms, Tobias Bauer, Juri-Alexander Witt, Tobias Baumgartner, Randi von Wrede, Attila Racz, Leon Ernst, Albert J. Becker, Christoph Helmstaedter, Rainer Surges, Theodor Rüber

Neurol Neuroimmunol Neuroinflamm 2023.

doi: 10.1212/NXI.0000000000200125

Convolutional Neural Network Algorithm to Determine

Lateralization of Seizure Onset in Patients With Epilepsy: A Proof-of-Principle Study (2023)

width-1200-png (1).png

Erik Kaestner, Jun Rao, Allen J. Chang, Zhong Irene Wang, Robyn M Busch, Simon S Keller, Theodor Rüber, Daniel L Drane, Travis Stoub, Ezequiel Gleichgerrcht, Leonardo Bonilha, Kyle Hasenstab, Carrie McDonald

Neurology 2023. doi: 10.1212/WNL.0000000000207411

Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease (2023)

MRI-based deep learning can discriminate between temporal lobe epilepsy,

Alzheimer's disease, and healthy controls (2023)

Artificial intelligence for the detection of focal cortical dysplasia:

Challenges in translating algorithms into clinical practice (2023)

The diagnostic value of ictal SPECT-A retrospective, semiquantitative monocenter study (2023)

The neurovasculature as a target in temporal lobe epilepsy (2023)

How to attribute Consciousness to the Non-Human? Hemispherotomy as a new challenge.

Gauvry C, Rüber T.

Journal of Neuroethics. [accepted]

Structural network alterations in focal and generalized epilepsy

assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression (2022)

Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data (2022)

Seymour M. Lopez, Leon M. Aksman, Neil P. Oxtoby, [...], Theodor Rüber, Ben Sinclair, Hamid Soltanian-Zadeh, [...] Andre Altmann, ENIGMA-Epilepsy Working Group

Epilepsia 2022. doi: 10.1111/epi.17316

Seizure underreporting in LGI1 and CASPR2 antibody encephalitis (2022)

Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long-term (2022)

A genome-wide association study in autoimmune neurological syndromes

with anti-GAD65 autoantibodies (2022)

Christine Strippel, Marisol Herrera-Rivero, Mareike Wendorff, [...], Theodor Rüber, Leon Ernst, [...], Nico Melzer

Brain 2022. doi: 10.1093/brain/awac119.

Large Phenotypic Variation of Individuals from a Family with a Novel ASPM Mutation

Associated with Microcephaly, Epilepsy, and Behavioral and Cognitive Deficits (2022)

Randi von Wrede, Martin Schidlowski, Hans-Jürgen Huppertz, Theodor Rüber,

Anja Ivo, Tobias Baumgartner, Kerstin Hallmann, Gábor Zsurka,

Christoph Helmstaedter, Rainer Surges and Wolfram S. Kunz

Genes 2022, 13, 429. doi: 10.3390/genes13030429

Shape description and volumetry of hippocampus and amygdala in temporal lobe epilepsy

- A beneficial combination with a clinical perspective (2022)

Antonia Harms, Tobias Bauer, Laura Fischbach, Bastian David, Leon Ernst,

Juri-Alexander Witt, Kersten Diers, Tobias Baumgartner, Bernd Weber,

Alexander Radbruch, Albert J Becker, Christoph Helmstaedter, Martin Reuter, Christian E Elger, Rainer Surges, Theodor Rüber

Epilepsy Behav. doi: 10.1016/j.yebeh.2022.108560

Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly. (2021)

Neumann K, Schidlowski M, Günther M, Stöcker T, Düzel E.

Front. Neurosci. doi: 10.3389/fnins.2021.711898

Infratentorial MRI findings in Rasmussen encephalitis suggest primary cerebellar involvement. (2021)

Reiter J*, David B*, Enders S, Prillwitz CC, Bauer T, Atalay D, Tietze A, Kaindl AM, Keil V, Radbruch A, Weber B, Becker A, Elger CE, Surges R, Rüber T.


Neurol Neuroimmunol Neuroinflamm. doi: 10.1212/nxi.0000000000001058


Functional redundancy of the premotor network in hemispherotomy patients. (2021)


Prillwitz CC, David B, Schlaug G, Deller T, Schramm J, Lindenberg R, Hattingen E, Weber B, Surges R, Elger CE, Rüber T.


Ann Clin Transl Neurol. doi: 10.1002/acn3.51427

Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: a worldwide ENIGMA-Epilepsy study. (2021)


Gleichgerrecht E, Munsell BC, Alhusaini S, [...], Rüber T, [...], McDonald CR, Bonilha L, ENIGMA-Epilepsy Working Group. 


Neuroimage Clin. doi: 10.1016/j.nicl.2021.102765

Heterotopia in individuals with 22q11.2 deletion syndrome: Arrested Arc cell migration? (2021)

Neuhaus E, Hattingen E, Breuer S, Steidl E, Polomac N, Rosenow R, Rüber T, Hermann E, Ecker C, Kushan L, Lin A, Vajdi A, Bearden CE, Jurcoane A.


AJNR Am J Neuroradiol. doi: 10.3174/ajnr.A7283

Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy. (2021)


Till S. Zimmer, Bastian David, Diede W. M. Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N. van der Wel, Peter C. van Rijen, Angelika Mühlebner, Wim van Hecke, Johannes C. Baayen, Sander Idema, Liesbeth François, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W. Kessels, Rainer Surges, Theodor Rüber, Jan A. Gorter, James D. Mills, Erwin A. van Vliet & Eleonora Aronica

Acta Neuropathologica. doi: 10.1007/s00401-021-02348-6

Permanent loss of independence in adult FIRES (Febrile Infection-Related Epilepsy Syndrome) survivors: an underestimated and unsolved challenge (2021).

Detection of Degenerative Changes on MR Images of the Lumbar Spine with a Convolutional Neural Network: A Feasibility Study (2021).

Treatment of progressive multifocal Leukoencephalopathy associated with idiopathic lymphocytopenia with Nivolumab (2021).

Ictal hypoperfusion and iron deposition in symptomatogenic zone of epilepsia partialis continua - A case report (2021).

External validation of automated focal cortical dysplasia detection using morphometric analysis (2021).

Systemic delivery of antagomirs during blood brain barrier disruption is disease-modifying in experimental epilepsy (2021).

Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC,  Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A,  Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp MJ, Henshall DC.

Mol Ther. doi: 10.1016/j.ymthe.2021.02.021.

Multi-scale image analysis and prediction of visual field defects after selective amygdalohippocampectomy (2021). 

Solidarität und Entwicklungszusammenarbeit. Einblicke in Vision und praktische Arbeit der Nichtregierungsorganisation CASA HOGAR Deutschland e.V. (2021)

Morales LJ, Schubert A, Rüber T.

In: Solidarität in Bewegung. Neue Felder für die Soziale Arbeit, Marc Hill und Caroline Schmitt, Hrsg. Band in der Reihe "Grundlagen der Sozialen Arbeit" - Baltmannsweiler: Schneider Verlag Hohengehren, 2021.

Reliability of quantitative transverse relaxation time mapping with T2-prepared whole brain pCASL (2020). 

pCASL (Schidlowski et al)

Schidlowski M, Stirnberg R, Stöcker T, Rüber T


SciRep 10:18299. doi: 10.1038/s41598-020-74680-y.

Structural network topology in limbic encephalitis is associated with amygdala enlargement, memory performance and serostatus (2020).

Structural network topology (Bauer et al

Bauer T, David B, Ernst L, Becker AJ, Witt J-A, Helmstaedter C, Wagner J, Weber B, Elger CE,  Surges R, Rüber T.

Epilepsia 61:e140-e145. doi: 10.1111/epi.16691.

Sharp wave-ripples in human amygdala and their coordination with hippocampus during NREM sleep (2020).

Sharp%20wave-ripples%20(Cox et al).jpg

Cox R, Rüber T, Staresina BP, Fell J.

Cerebral Cortex Communications 1:1-15. doi: 10.1093/texcom/tgaa051.

Blood-brain barrier permeability measurement by biexponentially modeling whole-brain arterial spin labeling data with multiple T2-weightings (2020).


Schidlowski M, Boland M, Rüber T*, Stöcker T*. 

NMR Biomed 33:e4374. doi: 10.1002/nbm.4374.

Contralesional White Matter Alterations in Patients After Hemispherotomy (2020).


Gaubatz J*, Prillwitz CC*, Ernst L, David B, Hoppe C, Hattingen E, Weber B, Vatter H, Surges R, Elger CE, Rüber T.

Front Hum Neurosci 14:262. doi: 10.3389/fnhum.2020.00262.

Fixel-based analysis links white matter characteristics, serostatus and clinical features in limbic encephalitis (2020).


Bauer T*,  Ernst L*, David B, Becker AJ, Wagner J, Witt J-A, Helmstaedter C, Weber B, Hattingen E, Elger CE,  Surges R, Rüber T.

Neuroimage Clin 27:e102289. 

Drebrin autoantibodies in patients with seizures and suspected encephalitis (2020).

Pitsch J, Kamalizade D, Braun A, Kuehn JC,  Gulakova PE, Rüber T, Lubec G, Dietrich D, von Wrede R, Helmstaedter C, Surges R,  Elger CE, Hattingen E, Vatter H, Schoch S, Becker AJ.

Ann Neurol 87(6):869-884

Phase-based coordination of hippocampal and neocortical oscillations during human sleep (2020). 

Cox R, Rüber T, Staresina BP, Fell J.

Commun Biol 3(1):176. doi: 10.1038/s42003-020-0913-5.

18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis (2019).

Deuschl C, Rüber TErnst L, Fendler W, Kirchner J, Herrmann K, Quesada C, Forsting M, Elger CE , Umutlu L.

PLoS One 15(1). doi: 10.1371/journal.pone.0227906.

Pyramidal tract and alternate motor fibers complementarily mediate motor compensation in patients after hemispherotomy (2019).

Gaubatz J*, Ernst L*, Prillwitz CC, David B, Lüchters G, Schramm J, Weber B, Surges R, Hattingen E, Schlaug G, Elger CE, Rüber T.

SciRep 10(1):1010. doi: 10.1038/s41598-020-57504-x.

Potent and lasting seizure suppression by systemic delivery of antagomirs targeting miR-134 timed with blood-brain barrier disruption (2019).

Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC,  Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A,  Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp MJ, Henshall DC.

doi: 10.1101/797621. [preprint]

No evidence for spontaneous cross-frequency phase-phase coupling in the human hippocampus (2019).

Rings T, Cox R, Rüber T, Staresina B, Lehnertz K, Fell J.

Eur J Neurosci 51(8):1735-1742. doi: 10.1111/ejn.14608.

Volumetry of mesiotemporal structures reflects serostatus in patients with limbic encephalitis (2019).

Ernst L, David B, Gaubatz J, Domínguez-Narciso I, Lüchters G, Becker AJ, Weber B, Hattingen E, Elger CE, Rüber T.

AJNR 40:2081-89. doi: 10.3174/ajnr.A6289.

Heterogeneous profiles of coupled sleep oscillations in human hippocampus (2019).

Cox R, Rüber T, Staresina BP, Fell J.

NeuroImage 202:116178. doi: 10.1016/j.neuroimage.2019.116178.

Sustained seizure freedom with transcutaneous vagal nerve stimulation in drug-resistant epilepsy caused by subcortical band heterotopias (2019).

vagal nerve stimulation.png

von Wrede R, Moskau-Hartmann S, Rüber T, Helmstaedter C, Surges R.

Seizure 70:25-26. doi: 10.1016/j.seizure.2019.06.026.

Morphometric MRI findings challenge the concept of the "unaffected" hemisphere in Rasmussen encephalitis (2019). 

Screenshot at 2019-04-16 15-17-49.png

David B, Prillwitz CC, Hoppe C, Sassen R, Hörsch S, Weber B, Hattingen E, Elger CE, Rüber T.

Epilepsia 60(5):e40-e46. doi: 10.1111/epi.14702.

Retinoencephalopathy with occipital lobe epilepsy in an OPA-1 mutation carrier (2019).


Nass RD, Hansen N, Quesada C, Rüber T, Kornblum C, Zsurka G, Hermann P, Becker A, Gärtner F, Hattingen E, Block W, Steidl E, Elger CE, Surges R, Kunz WS.

Seizure 66:1-3. doi: 10.1016/j.seizure.2019.01.029.

Evidence for peri-ictal blood-brain barrier dysfunction in patients with epilepsy (2018).

Rüber T*, David B*, Lüchters G, Nass RD, Friedman A, Surges R, Stöcker T, Weber B, Deichmann R, Schlaug G, Hattingen E, Elger CE.

Brain 141(10):2952–2965. doi: 10.1093/brain/awy242. 

Limbic Encephalitis in Patients with Epilepsy—is Quantitative MRI Diagnostic? (2018).

Schievelkamp AH, Jurcoane A, Rüber T, Ernst L, Müller A, Mädler B, Schild HH, Hattingen E.

Clin Neuroradiol 29(4):623-630. doi: 10.1007/s00062-018-0705-1.

The salience network and human personality: Integrity of white matter tracts within anterior and posterior salience network relates to the self-directedness character trait (2018).

Prillwitz CC*, Rüber T*, Reuter M, Montag C, Weber B, Elger CE, Markett S.

Brain Res 1692:66-73. doi: 10.1016/j.brainres.2018.04.035.

MRI in epilepsy: clinical standard and evolution (2018).

MRI clinical standard.png

Rüber T, David B, Elger CE.

Curr Opin Neurol 31(2):223-231. doi: 10.1097/WCO.0000000000000539.

Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy (2018).

Hansen N, Ernst L, Rüber T, Widman G, Becker AJ, Elger CE, Helmstaedter C.

Epilepsy Behav 79:93-99. doi: 10.1016/j.yebeh.2017.10.033.

Repair after brainstem ischemia involves neurogenesis and the rubrospinal system (2018).

Rüber T, Schlaug G.

Ann Neurol 83(6):1069-1071. doi: 10.1002/ana.25265.

Diffusion Tensor Imaging and Tractography (2016).

Rüber T, Elger CE, Weber B.

In: Montag C, Reuter M, (Ed.). Neuroeconomics – Studies in Neuroscience, Psychology and Behavioral Economics.Luxemburg – Berlin, Springer.

* equal contribtution

Former publications of individual group members

Chronic Presence of Oligomeric Aβ Differentially Modulates Spine Parameters in the Hippocampus and Cortex of Mice With Low APP Transgene Expression (2020). Hrynchak MV, Rierola M, Golovyashkina N, Penazzi L, Pump WC, David B, Sündermann F, Brandt R, Bakota L.Front Synaptic Neurosci 12:16. doi: 10.3389/fnsyn.2020.00016.

Accelerated aortic 4D flow cardiovascular magnetic resonance using compressed sensing: applicability, validation and clinical integration (2019). Neuhaus E, Weiss K, Bastkowski R, Koopmann J, Maintz D, Giese D. J Cardiovasc Magn Reson 21:65. doi: 10.1186/s12968-019-0573-0.

Other-regarding attention focus modulates third-party altruistic choice: An fMRI study (2017). David B, Hu Y, Krüger F, Weber B.Sci Rep 7:43024. doi: 10.1038/srep43024.


The (non-)replicability of regulatory resource depletion: A field report employing non-invasive brain stimulation (2017).

Emmerling F, Martijn C, Alberts HJ, Thomson AC, David B, Kessler D, Schuhmann T, Sack AT. PLoS One 12(3):e0174331. doi: 10.1371/journal.pone.0174331.

The Effect of Oxytocin on Third-Party Altruistic Decisions in Unfair Situations: An fMRI Study (2016).

Hu Y, Scheele D, Becker B, Voos G, David B, Hurlemann R, Weber B. Sci Rep 6:20236. doi: 10.1038/srep20236.

Differential adaption of descending motor tracts in musicians (2015). Rüber T, Lindenberg R, Schlaug G. Cereb Cortex 25:1490-1498. doi: 10.1093/cercor/bht331.

Compensatory role of the cortico-rubro-spinal tract in motor recovery after stroke (2012). Rüber T, Schlaug G, Lindenberg R. Neurology 79:515-522. doi: 10.1212/WNL.0b013e31826356e8.

Effects of practice and experience on the arcuate fasciculus: comparing singers, instrumentalists, and non-musicians (2011).

Halwani G, Loui P, Rüber T, Schlaug G. Front Psychol 2:156. doi: 10.3389/fpsyg.2011.00156.

Predicting functional motor recovery in chronic stroke patients using Diffusion Tensor Imaging (2011). Lindenberg R, Zhu LL, Rüber T, Schlaug G. Hum Brain Mapp 33:1040-1051. doi: 10.1002/hbm.21266.


The therapeutic effects of singing in neurological disorders (2010). Wan CY, Rüber T, Hohmann A, Schlaug G. Music Percept 27(4):287-295. doi: 10.1525/mp.2010.27.4.287.

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