top of page

Until today, MRI in epilepsy has focused on neurostructural pathologies causing seizures, whereas the epileptic seizures as such, albeit being the pathognomonic symptoms of epilepsy, have not received any attention. Here, we want to establish functional MR imaging of epileptic seizures by sensitizing our MRI signal and data postprocessing for what is commonly known as transient peri-ictal MRI changes. As epileptic seizures of patients may not directly be observed in the scanner for pragmatic reasons, the idea is to post-hoc visualize microstructural processes anatomically and temporally related to individual seizures, such as peri-ictal blood-brain barrier dysfunction (Rüber, David et al., 2018a) or postictal hypoperfusion (Gaxiola-Valdez et al., 2017). First studies in our group have confirmed that peri-ictal blood-brain barrier dysfunction may be measured by means of post-ictal quantitative MRI after ictal injection of Gadolinium and could be visualized peri-focally after elaborate postprocessing on a single-subject level (see figure). The ictal injection of Gadolinum, however, is time-consuming and the medical harmlessness of Gadolinium itself is in the focus of a controversial scientific debate. In collaboration with Professor Tony Stöcker from the DZNE, an Arterial Spin Labeling MR sequence is being developed which may measure both at the same time: blood-brain barrier permeability and perfusion by means of an endogenous tracer, i.e. without exogenous contrast agent application (and, thus, without the need for a technical-assistant observing the patient to ensure strictly ictal injection of contrast agent). 


ΔT1 indicating postictal enhancement of gadolinium-based contrast agent in three patient. ΔT1computed by subtracting postictal qT1 from interictal qT1. Higher ΔT1 values, thus, reflect a greater postictal enhancement of contrast agent.

Patient 1: MRI: hippocampal sclerosis, ictal EEG onset: left temporal, presumed seizure onset zone: left mesio-temporal, patient showed focal seizure
Patient 2: MRI: resected cavernoma in left temporal lobe, ictal EEG onset: left temporal, presumed seizure onset zone: left temporal, patient showed focal seizure
Patient 3: MRI: negative, showed ictal EEG onset: right frontal, presumed SOZ: right frontal, patient showed generalized seizure

Arterial Spin Labeling

Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique which uses protons of the blood as endogenous tracers. For this purpose, arterial protons are marked within caudally located layers by applying magnetization inverting radiofrequency pulses. Similar to contrast-enhanced magnetic resonance imaging with exogenous contrast agents, there is a decrease of longitudinal magnetization and the initial state is gradually restored while the protons perfuse into the cerebral vascular system. By subsequent imaging of the brain, the MR signal of the marked protons is reduced compared to unmarked images because they have not yet reached their equilibrium state. The difference between the marked image and a control image corresponds to perfusion.

Reliability of quantitative transverse relaxation time mapping with T2-prepared whole brain pCASL. Schidlowski et al. (2020).SciRep 10:18299, doi: 10.1038/s41598-020-74680-y.

Blood-brain barrier permeability measurement by biexponentially modeling whole-brain arterial spin labeling data with multiple T2-weightings. Schidlowski et al. (2020). NMR Biomed 33:e4374 doi: 10.1002/nbm.4374.

bottom of page